SIDT2
Description
The SIDT2 (SID1 transmembrane family member 2) is a protein-coding gene located on chromosome 11.
SIDT2 is a protein encoded by the SIDT2 gene in humans. It belongs to the SID1 transmembrane family.
SIDT2 mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA). This process involves the direct import of RNA or DNA into lysosomes in an ATP-dependent manner, leading to their degradation. SIDT2 is also involved in the uptake of single-stranded oligonucleotides by living cells, a process known as gymnosis. In vitro studies have shown that SIDT2 mediates the uptake of linear DNA more efficiently than circular DNA, while exhibiting similar uptake efficacy towards RNA and DNA. SIDT2 binds long double-stranded RNA (dsRNA) with a length of 500-700 base pairs, but not dsRNA shorter than 100 bp. It interacts with adapter protein complex 1 (AP-1) and AP-2, but not AP-3 and AP-4. SIDT2 has also been shown to interact with LAMP2.
SIDT2 is also known as CGI-40.
