SH3PXD2A
Description
The SH3PXD2A (SH3 and PX domains 2A) is a protein-coding gene located on chromosome 10.
SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.
SH3PXD2A plays a role in invadopodia and podosome formation, which are structures involved in extracellular matrix degradation and cancer cell invasion. It binds to matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs), and phosphoinositides, acting as an organizer protein that facilitates reactive oxygen species (ROS) generation and localization. In collaboration with ADAM12, it contributes to the neurotoxic effects of amyloid-beta peptide.
SH3PXD2A is also known as FISH, SH3MD1, TKS5.
