SH3BGRL3
Description
The SH3BGRL3 (SH3 domain binding glutamate rich protein like 3) is a protein-coding gene located on chromosome 1.
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) is a protein encoded by the SH3BGRL3 gene in humans. It is a small protein with a significant similarity to glutaredoxin 1 of E. coli, and all three proteins are predicted to belong to the thioredoxin-like protein family. Glutaredoxins (GRXs) are ubiquitous oxidoreductases that catalyze the reduction of many intracellular protein disulfides and play an important role in many redox pathways. However, SH3BGRL3 lacks the enzymatic function of glutaredoxins and may have a role as a regulator of redox activity. SH3BGRL3 has been found to be upregulated in glioblastoma multiforme compared to normal cerebral tissue, suggesting a potential role in cancer. It has also been reported to be upregulated in acute promyelocytic leukemia cell line NB4. The gene encoding SH3BGRL3 is located on human chromosome 1p34.3-35. Two homologous genes, SH3BGRL and SH3BGR, are located on chromosome Xq13.3 and chromosome 21, respectively. These genes encode small proteins similar to the N-terminal region of the SH3BGR protein.
SH3BGRL3 is also known as HEL-S-297, SH3BP-1, TIP-B1.
Associated Diseases
- asthma
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type
- hyperkeratosis lenticularis perstans
- ichthyosis histrix, Lambert type
- palmoplantar keratoderma-deafness syndrome
- cancer
