SGK3

Description

The SGK3 (serum/glucocorticoid regulated kinase family member 3) is a protein-coding gene located on chromosome 8.

SGK3 is an enzyme encoded by the SGK3 gene in humans. It belongs to the serine/threonine protein kinase family and is a phosphoprotein with a PX (phox homology) domain. SGK3 phosphorylates various target proteins and plays a crucial role in neutral amino acid transport and the activation of potassium and chloride channels. Multiple isoforms of SGK3 are produced through alternative splicing.

SGK3 plays a significant role in regulating a wide range of cellular processes, including ion channel activity, membrane transporter function, cell growth, proliferation, survival, and migration. It enhances the activity of various ion channels, such as sodium channels (SCNN1A/ENAC and SCN5A), potassium channels (KCNA3/KV1.3, KCNE1, KCNQ1, and KCNH2/HERG), epithelial calcium channels (TRPV5 and TRPV6), and chloride channels (BSND). SGK3 also regulates the activity of numerous transporters, including the creatine transporter (SLC6A8), the sodium/dicarboxylate cotransporter (SLC13A2/NADC1), the sodium-dependent phosphate cotransporter (SLC34A2/NAPI-2B), amino acid transporters (SLC1A5/ASCT2 and SLC6A19), glutamate transporters (SLC1A3/EAAT1, SLC1A6/EAAT4, and SLC1A7/EAAT5), glutamate receptors (GRIA1/GLUR1 and GRIK2/GLUR6), the sodium/hydrogen exchanger (SLC9A3/NHE3), and the sodium/potassium ATPase. Additionally, SGK3 plays a role in regulating renal tubular phosphate transport and bone density. It exerts its effects through phosphorylation of various target proteins, including NEDD4L, GSK3B, and FLII. Phosphorylation of FLII leads to increased ER transcription activity, while phosphorylation of ITCH/AIP4 inhibits its function, preventing CXCR4 from being efficiently degraded. SGK3 interacts with GSK3B, FLII, and PDPK1 in a phosphorylation-dependent manner.

SGK3 is also known as CISK, SGK2, SGKL.

Associated Diseases

WES Whole Exome Sequencing