SGK2
Description
The SGK2 (serum/glucocorticoid regulated kinase 2) is a protein-coding gene located on chromosome 20.
The SGK2 gene encodes a serine/threonine protein kinase that is similar to serum- and glucocorticoid-induced protein kinase (SGK), but unlike SGK, is not induced by serum or glucocorticoids. However, SGK2 is induced by signals that activate phosphatidylinositol 3-kinase (PI3K), similar to SGK. Two alternate transcripts encoding two different isoforms have been described for SGK2.
SGK2 is a serine/threonine-protein kinase that regulates a diverse array of ion channels, membrane transporters, and cellular processes, including growth, survival, and proliferation. It has been shown to upregulate various channels and transporters including Na(+) channels (SCNN1A/ENAC), K(+) channels (KCNA3/Kv1.3, KCNE1, and KCNQ1), amino acid transporter (SLC6A19), glutamate transporter (SLC1A6/EAAT4), glutamate receptors (GRIA1/GLUR1 and GRIK2/GLUR6), Na(+)/H(+) exchanger (SLC9A3/NHE3), and the Na(+)/K(+) ATPase. These regulatory effects are supported by a number of research publications (PubMed:12397388, 12590200, 12632189, 12634932, 15040001, 20511718, 21865597).
SGK2 is also known as H-SGK2, dJ138B7.2.
