SGIP1
Description
The SGIP1 (SH3GL interacting endocytic adaptor 1) is a protein-coding gene located on chromosome 1.
SGIP1 (SH3-containing GRB2-like protein 3-interacting protein 1) is a protein encoded by the SGIP1 gene in humans.
SGIP1 is involved in clathrin-mediated endocytosis, a process that brings molecules into cells. It has the ability to bind to and shape membranes, and recruit other proteins that are necessary for the formation of clathrin-coated pits, which are structures involved in endocytosis. SGIP1 prefers membranes that are rich in specific lipids like phosphatidylserine and phosphoinositides. It is essential for the uptake of the transferrin receptor, a protein involved in iron transport. SGIP1 may also interact with tubulin, a protein that forms microtubules, which are important for cell structure and transport. Additionally, SGIP1 may play a role in regulating energy balance within the cell.
SGIP1 is also known as -.
