SFTPD
Description
The SFTPD (surfactant protein D) is a protein-coding gene located on chromosome 10.
SP-D (Surfactant protein D) is a vital component of the innate immune system, found within the lungs. Encoded by the SFTPD gene, it belongs to the collagenous lectin family, called collectins. Each SP-D subunit is made up of four distinct regions: an N-terminal domain, a collagenous segment, a neck region, and a lectin domain at the C-terminus. Three of these subunits assemble into a trimer, and multiple trimers further associate to form a tetrameric complex. SP-D has been shown to interact with DMBT1 and the hemagglutinin of influenza A virus. Its function can be modified through post-translational modifications like S-nitrosylation.
SP-D plays a crucial role in protecting the lungs from inhaled threats, including microorganisms, allergens, and toxins. It interacts with various compounds like bacterial lipopolysaccharides, sugars, and fatty acids, influencing the behavior of immune cells. Additionally, it may be involved in the restructuring and breakdown of lung surfactant. SP-D exhibits a strong affinity for maltose and to a lesser degree, other alpha-glucose-containing molecules.
SFTPD is also known as COLEC7, PSP-D, SFTP4, SP-D.
