SFTPA2
Description
The SFTPA2 (surfactant protein A2) is a protein-coding gene located on chromosome 10.
Surfactant protein A2 (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2), is a protein encoded by the SFTPA2 gene in humans. Primarily synthesized in lung alveolar type II cells, it's a component of pulmonary surfactant, a complex of lipids and proteins that reduces surface tension in the alveolus, preventing collapse during expiration. This protein plays a role in modulating the innate immune response and inflammatory processes. SP-A2 belongs to the collectin family of C-type lectins and is one of the most abundant proteins in pulmonary surfactant, alongside SP-A1. It binds to carbohydrates on the surface of various microorganisms, contributing to defense against respiratory pathogens. Surfactant homeostasis is crucial for breathing and lung health throughout life. Alterations in surfactant composition or function are linked to respiratory diseases. While primarily expressed in the lungs, SFTPA2 mRNA has also been detected in the trachea, prostate, pancreas, thymus, colon, eye, salivary gland, and other tissues.
SFTPA2 is also known as COLEC5, ILD2, PSAP, PSP-A, PSPA, SFTP1, SFTPA2B, SP-2A, SP-A, SPA2, SPAII.
