SFRP2
Description
The SFRP2 (secreted frizzled related protein 2) is a protein-coding gene located on chromosome 4.
SFRP2 is a gene that encodes a protein belonging to the SFRP family, which contains a cysteine-rich domain homologous to the Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of the SFRP2 gene has been identified as a potential marker for colorectal cancer. Furthermore, research in mice has shown that SFRP2 plays a role in regenerating cardiomyocytes, suggesting its potential in treating heart injuries. SFRP2 expression has been observed to be progressively overexpressed in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at various stages of malignancy. This finding suggests a possible link between SFRP2 and tumorigenesis, and its potential as a prognostic marker for the progression of uterine cervical preneoplastic lesions.
SFRP2 is also known as FRP-2, SARP1, SDF-5.
Associated Diseases
- syndactyly type 1
- isolated congenital digital clubbing
- syndactyly type 3
- extensor tendons of finger anomalies
- polysyndactyly 4
- syndactyly type 4
- hallux varus-preaxial polysyndactyly syndrome
