SFRP1
Description
The SFRP1 (secreted frizzled related protein 1) is a protein-coding gene located on chromosome 8.
SFRP1 is a protein encoded by the SFRP1 gene. It belongs to the SFRP family, which contains a cysteine-rich domain similar to the Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP1, along with SFRP5, may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in various human tissues, with the highest levels found in the heart. The SFRP family consists of five secreted glycoproteins in humans (SFRP1, SFRP2, SFRP3, SFRP4, SFRP5) that act as extracellular signaling ligands. Each SFRP is approximately 300 amino acids long and contains a cysteine-rich domain (CRD) that shares 30-50% sequence homology with the CRD of Frizzled (Fz) receptors. SFRPs can bind to Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding to Fz receptors, thus downregulating Wnt signaling. SFRPs can also form an inhibitory complex with Frizzled receptors, further downregulating Wnt signaling.
SFRP1 is also known as FRP, FRP-1, FRP1, FrzA, SARP2.
