SERTAD3
Description
The SERTAD3 (SERTA domain containing 3) is a protein-coding gene located on chromosome 19.
SERTAD3 is an antiviral interferon-stimulated protein that plays a role in innate immunity and the suppression of viruses through different mechanisms. It contributes to the late phase response of TLR-induced immune effector expression. During influenza infection, SERTAD3 interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex. It also inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation. SERTAD3 is a strong transcriptional coactivator.
SERTAD3 is also known as RBT1.
