SERP1

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Description

The SERP1 (stress associated endoplasmic reticulum protein 1) is a protein-coding gene located on chromosome 3.

Stress-associated endoplasmic reticulum protein 1 is a protein that in humans is encoded by the SERP1 gene.

SERP1 interacts with target proteins as they are transported into the endoplasmic reticulum (ER). During ER stress, SERP1 safeguards unfolded proteins from degradation. After stress subsides, it potentially helps in glycosylation of target proteins. It may also influence the selection of N-glycosylation sites on target proteins.

SERP1 is also known as RAMP4.

Associated Diseases

• congenital hypothyroidism
• hyperinsulinism due to INSR deficiency
• hyperinsulinism due to glucokinase deficiency
• hypoinsulinemic hypoglycemia and body hemihypertrophy
• transient neonatal diabetes mellitus
• hyperinsulinemic hypoglycemia, familial, 1
• generalized resistance to thyroid hormone
• glioblastoma
• polyendocrine-polyneuropathy syndrome
• pituitary hormone deficiency, combined, 6
• exercise-induced hyperinsulinism
• pituitary adenocarcinoma
• thyroid hormone metabolism, abnormal 1
• hyperinsulinism-hyperammonemia syndrome
• obesity due to pro-opiomelanocortin deficiency