SEPT4-AS1
The sept4-as1 Gene: A Comprehensive Guide
Description
The sept4-as1 gene, also known as SEPT4 Antisense RNA 1, is a long non-coding RNA (lncRNA) located on chromosome 1q22. LncRNAs are non-protein-coding RNA molecules that play crucial roles in gene regulation, development, and disease.
Associated Diseases
Dysregulation of the sept4-as1 gene has been implicated in various diseases, including:
- Colorectal cancer: Sep4-as1 is overexpressed in colorectal cancer and promotes tumor growth and metastasis.
- Breast cancer: Sep4-as1 is upregulated in breast cancer and is associated with poor prognosis.
- Liver cancer: Sep4-as1 is a key regulator of liver cancer cell proliferation and invasion.
- Renal cell carcinoma: Sep4-as1 is involved in the development and progression of renal cell carcinoma.
- Neuroblastoma: Sep4-as1 promotes cell proliferation, migration, and angiogenesis in neuroblastoma.
Did you Know ?
According to a recent study, the overexpression of sept4-as1 in colorectal cancer is associated with a significantly shorter overall survival rate. Patients with high sept4-as1 expression had a median survival time of 38.6 months compared to 63.4 months in patients with low sept4-as1 expression.