SENP3-EIF4A1
Description
The SENP3-EIF4A1 (SENP3-EIF4A1 readthrough (NMD candidate)) is a ncRNA gene located on chromosome 17.
SENP3-EIF4A1 is a chimeric protein formed by the fusion of the SENP3 and EIF4A1 genes. The SENP3 portion of the fusion protein has SUMO isopeptidase activity, while the EIF4A1 portion is an RNA helicase involved in translation initiation. The fusion is a result of a chromosomal translocation and may disrupt normal cellular processes related to SUMOylation and translation.
SENP3-EIF4A1 is a fusion protein resulting from a chromosomal translocation. The precise function of this fusion protein remains to be fully elucidated, but it is likely to be involved in the regulation of gene expression and cellular growth. The SENP3 portion of the protein possesses SUMO (Small Ubiquitin-like Modifier) isopeptidase activity, which is involved in the removal of SUMO from target proteins, thereby impacting protein stability and activity. EIF4A1, on the other hand, is an RNA helicase that participates in the initiation of protein synthesis. Therefore, the fusion of SENP3 and EIF4A1 may disrupt normal SUMOylation and translation processes, potentially contributing to cellular dysfunction and the development of certain diseases.
SENP3-EIF4A1 is also known as -.
