SENP3
Description
The SENP3 (SUMO specific peptidase 3) is a protein-coding gene located on chromosome 17.
SENP3, also known as SUMO1/sentrin/SMT3 specific peptidase 3, is a protein encoded by the SENP3 gene. It is part of the Ulp1 branch in yeast and localizes to the nucleolus through B23/NPM1. SENP3 is associated and regulated by B23/nucleophosmin/NPM1 and involved in the regulation of ribosome biogenesis. It may be regulated by the Arf-Mdm2-p53 pathway.
SENP3 is a protease that removes SUMO2 and SUMO3 from proteins (sumoylated substrates), but has a weaker effect on SUMO1. It plays a role in regulating the activity of various proteins by removing SUMO2/3, including: MEF2D (increasing its transcriptional activity), CDCA8, EP300 (enhancing HIF1A activity), NPM1 (essential for rRNA processing), and ZNF148 (regulating its sumoylation status). SENP3 is part of the 5FMC complex, which interacts with methylated CHTOP and ZNF148, leading to desumoylation of ZNF148 and activation of its target genes. SENP3 also removes SUMO2 from KAT5.
SENP3 is also known as SMT3IP1, SSP3, Ulp1.
