SEMA6A
Description
The SEMA6A (semaphorin 6A) is a protein-coding gene located on chromosome 5.
Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.
SEMA6A acts as a cell surface receptor for PLXNA2, contributing significantly to cell-cell signaling. It is essential for proper granule cell migration in the developing cerebellum. Additionally, SEMA6A promotes reorganization of the actin cytoskeleton and plays a crucial role in guiding axons during development of the central nervous system. It can act as a repulsive cue for axon guidance and exhibits repulsive effects on migrating granular neurons. SEMA6A may also be involved in directing sympathetic axons into sympathetic chains and regulating the timing of sympathetic target innervation.
SEMA6A is also known as HT018, SEMA, SEMA6A1, SEMAQ, VIA.
Associated Diseases
- delayed puberty, self-limited
- thyroid gland adenocarcinoma
- nonpapillary renal cell carcinoma
- Mobius syndrome
- cancer
- breast cancer
