SEMA5A
Description
The SEMA5A (semaphorin 5A) is a protein-coding gene located on chromosome 5.
Semaphorin-5A is a protein encoded by the SEMA5A gene in humans. Members of the semaphorin protein family, including SEMA5A, play a role in axonal guidance during neural development. Semaphorin 5A is also implicated in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.
Semaphorin-5A acts as a bifunctional axonal guidance cue, influenced by sulfated proteoglycans. Its attractive effects arise from interactions with heparan sulfate proteoglycans (HSPGs), while inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). It serves as a ligand for the receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 leads to disassembly of F-actin stress fibers, disruption of focal adhesions, cellular collapse, and inhibition of cell migration and invasion via ARHGDIA-mediated inactivation of RAC1. It may promote angiogenesis by enhancing endothelial cell proliferation, migration, and inhibiting apoptosis.
SEMA5A is also known as SEMAF, semF.
