SEMA3F
Description
The SEMA3F (semaphorin 3F) is a protein-coding gene located on chromosome 3.
Semaphorin-3F is a protein encoded by the SEMA3F gene in humans. Semaphorins are a family of proteins involved in signaling, characterized by a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues. Semaphorin-3F belongs to the semaphorin 3 family, which includes human semaphorins 3A-G, chicken collapsin, and mouse semaphorins 3A-G. This family shares a basic domain at the C terminus. Chicken collapsin, a member of this family, influences axon pathfinding during development by inhibiting growth cone extension. This inhibition occurs through interaction with CRMP62, a protein related to UNC33, which is involved in axonal guidance.
SEMA3F is also known as SEMA-IV, SEMA4, SEMAK.
