SEMA3A
Description
The SEMA3A (semaphorin 3A) is a protein-coding gene located on chromosome 7.
Semaphorin-3A is a protein encoded by the SEMA3A gene. It belongs to the semaphorin family and has an Ig-like C2-type domain, a PSI domain, and a Sema domain. This secreted protein acts as a chemorepulsive agent, inhibiting axonal outgrowth, and as a chemoattractive agent, stimulating apical dendrite growth. These dual functions are essential for the development of normal neuronal patterns. Semaphorin-3A is secreted by neurons and surrounding tissue to guide migrating cells and axons during development. Axon pathfinding, a critical process for precise neuron formation and vasculature development, relies on guidance cues like Semaphorin-3A. These cues induce growth cone collapse and paralysis during nervous system development. The signaling pathway for Semaphorin-3A involves receptor complexes containing Neuropilin-1 (NRP1) and a co-receptor, with CRMP2 being one of the identified intracellular messengers.
SEMA3A is also known as COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1.
