SEC61G
Description
The SEC61G (SEC61 translocon subunit gamma) is a protein-coding gene located on chromosome 7.
The Sec61 complex is the key component of the protein translocation apparatus in the endoplasmic reticulum (ER) membrane. It forms a transmembrane channel through which proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins: alpha, beta, and gamma. SEC61G encodes the gamma-subunit protein. Alternative splicing of the gene results in different transcript variants that encode the same protein.
The SEC61 channel is a critical component of the protein translocation apparatus in the endoplasmic reticulum (ER) membrane. It forms a gated pore that allows for the transport of precursor proteins across the ER membrane. The channel acts as a ribosome receptor and facilitates the cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in the insertion of transmembrane proteins into the ER membrane, mediating the insertion of the initial transmembrane segments. The insertion of subsequent transmembrane regions in multi-pass membrane proteins is handled by the multi-pass translocon (MPT) complex. The SEC61 channel collaborates with the translocating protein TRAM1 to import nascent proteins into the ER.
SEC61G is also known as SSS1.
