SEC61B
Description
The SEC61B (SEC61 translocon subunit beta) is a protein-coding gene located on chromosome 9.
SEC61B is a gene that encodes the beta subunit of the Sec61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. It consists of three membrane proteins: alpha, beta, and gamma. The Sec61 subunits have also been observed in the post-ER compartment, suggesting that they can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
SEC61B is a component of the SEC61 channel-forming translocon complex, which mediates the transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). It forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel also mediates the membrane insertion of the first few transmembrane segments of proteins. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
SEC61B is also known as -.
Associated Diseases
- asthma
- polycystic liver disease 1
- hyperinsulinism due to INSR deficiency
- exercise-induced hyperinsulinism
- glycogen storage disease due to glycogen branching enzyme deficiency
- hyperinsulinism due to glucokinase deficiency
- substance abuse
