SDCBP
Description
The SDCBP (syndecan binding protein) is a protein-coding gene located on chromosome 8.
SDCBP encodes syntenin-1, a protein initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. It contains tandemly repeated PDZ domains that bind to the cytoplasmic, C-terminal domains of various transmembrane proteins. SDCBP may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and transcription factor activation. Primarily localized to membrane-associated adherens junctions and focal adhesions, it is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
SDCBP, also known as syntenin-1, is a multifunctional adapter protein involved in a variety of cellular processes, including transmembrane protein trafficking, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. It positively regulates TGFβ1-mediated SMAD2/3 activation and TGFβ1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. SDCBP may increase TGFβ1 signaling by enhancing cell-surface expression of TGFβR1, preventing its interaction with CAV1 and subsequent CAV1-dependent internalization and degradation. In collaboration with SDC1/4 and PDCD6IP, it regulates exosome biogenesis. SDCBP also regulates migration, growth, proliferation, and cell cycle progression in various cancer types. Within adherens junctions, it may couple syndecans to cytoskeletal proteins or signaling components. SDCBP appears to link the transcription factor SOX4 to the IL-5 receptor (IL5RA), and may also play a role in vesicular trafficking. It is required for the targeting of TGFA to the cell surface in the early secretory pathway.
SDCBP is also known as MDA-9, MDA9, SDCBP1, ST1, SYCL, TACIP18.
