SCUBE2
Description
The SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2) is a protein-coding gene located on chromosome 11.
SCUBE2 is a protein that plays a role in long-range SHH signaling and angiogenesis. It is a lipid-binding protein that binds to dually lipid-modified SHH (ShhNp) and promotes its release from the cell membrane. SCUBE2 also enhances the proteolytic processing of ShhNp and acts as a potential cell surface coreceptor for VEGFR2.
SCUBE2 is a lipid-binding protein that plays a crucial role in long-range Sonic hedgehog (SHH) signaling. It binds to dually lipid-modified SHH (ShhNp) and facilitates its mobilization, solubilization, and release from the cell membrane. SCUBE2 enhances the proteolytic processing of ShhNp's lipid-modified N- and C-termini at the cell surface. It collaborates with DISP1 to increase SHH secretion. Additionally, SCUBE2 acts as a potential cell surface coreceptor for VEGFR2, participating in VEGFR2-mediated angiogenesis.
SCUBE2 is also known as CEGB1, CEGF1, CEGP1, scube/You.
Associated Diseases
- breast cancer
- Eiken syndrome
- lipodystrophy-intellectual disability-deafness syndrome
- rhizomelic chondrodysplasia punctata type 3
- multiple epiphyseal dysplasia type 1
- multiple epiphyseal dysplasia type 4
- autosomal dominant osteosclerosis, Worth type
- multiple epiphyseal dysplasia type 5
- pseudopseudohypoparathyroidism
- hip dysplasia, Beukes type
