SCTR
Description
The SCTR (secretin receptor) is a protein-coding gene located on chromosome 2.
SCTR may refer to: Secretin receptor (SCT-R), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis.
The secretin receptor (SCTR) is a G protein-coupled receptor that binds to the hormone secretin. It is involved in regulating the pH of the duodenum, promoting satiation through diet-induced thermogenesis, regulating renal water reabsorption, and contributing to synaptic plasticity in the central nervous system. Upon binding to secretin, SCTR activates adenylyl cyclase, leading to the production of cAMP. This triggers a cascade of events that include inhibiting gastric acid secretion, stimulating bicarbonate production in the pancreas, activating brown fat thermogenesis through lipolysis, and promoting water reabsorption in the kidneys. SCTR also plays a role in osmoregulation by mediating renal water reabsorption and is involved in neuronal signaling in the central nervous system.
SCTR is also known as SR.
Associated Diseases
- ovarian cancer
- schizophrenia
- nephronophthisis
- familial idiopathic steroid-resistant nephrotic syndrome
- Senior-Loken syndrome
- Dent disease
- focal segmental glomerulosclerosis 7
- nephronophthisis 1
- congenital nephrotic syndrome, Finnish type
- nephronophthisis 3
- Senior-Loken syndrome 1
