SCT

Description

The SCT (secretin) is a protein-coding gene located on chromosome 11.

SCT is a gene that encodes the protein secretin, a hormone involved in various processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. It exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis. Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance.

The SCT gene encodes a hormone, secretin, which is involved in various physiological processes, including the regulation of pH in the duodenum, food intake, and water homeostasis. Secretin acts by binding to its receptor, SCTR, a G-protein coupled receptor expressed in several cells. It plays a critical role in regulating the pH of the duodenum by inhibiting gastric acid secretion from the stomach and stimulating bicarbonate production from the pancreas, thus protecting the small intestine from damage. Secretin also contributes to diet-induced thermogenesis by activating brown fat thermogenesis, leading to satiation. It is involved in cellular osmoregulation, regulating water homeostasis through actions in the hypothalamus, pituitary, and kidney. Furthermore, secretin may act as a neuropeptide hormone in the central nervous system, influencing hippocampal synaptic function and neural progenitor cell maintenance.

SCT is also known as -.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing