SCN10A : sodium voltage-gated channel alpha subunit 10

Description

The SCN10A (sodium voltage-gated channel alpha subunit 10) is a protein-coding gene located on chromosome 3.

The SCN10A gene produces instructions for making a sodium channel called NaV1.8. This channel is found in pain-sensing nerve cells called nociceptors, which are part of the peripheral nervous system. NaV1.8 plays a critical role in transmitting pain signals from the body to the brain and spinal cord. While primarily involved in pain signaling, NaV1.8 has also been found in heart muscle cells, where it likely contributes to regulating heart rhythm.

SCN10A is also known as FEPS2, Nav1.8, PN3, SNS.

Associated Diseases

• Brugada syndrome
• Paroxysmal extreme pain disorder
• Episodic pain syndrome, familial, 2
• Primary erythromelalgia
• Romano-Ward syndrome
• Small fiber neuropathy