SCIMP

---

Description

The SCIMP (SLP adaptor and CSK interacting membrane protein) is a protein-coding gene located on chromosome 17.

SCIMP (Silent Circle Instant Message Protocol) was an encryption scheme developed by Vincent Moscaritolo of Silent Circle. It enabled private conversation over instant message transports such as XMPP (Jabber), providing encryption, perfect forward secrecy, and message authentication. SCIMP handled negotiating the shared secret keys. Silent Circle used SCIMP in their encrypted instant messaging application called Silent Text. Silent Text was discontinued on September 28, 2015, when its features were merged into Silent Circle's encrypted voice calling application called Silent Phone.

SCIMP acts as a scaffold for Src-family kinases and other signaling proteins in immune cells, facilitating signal transduction in response to various stimuli. In B cells, it is required for MHC-II signaling, contributing to calcium response and ERK activation. In dendritic cells, it sustains CLEC7A/DECTIN1 signaling after fungal beta-glucan activation. It also serves as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7, enabling the selective expression of pro-inflammatory cytokines IL6 and IL12B in macrophages.

SCIMP is also known as C17orf87, UNQ5783.

Associated Diseases

• Alzheimer disease
• hemoglobin E-beta-thalassemia syndrome
• Rh deficiency syndrome
• X-linked sideroblastic anemia 1
• cholesterol-ester transfer protein deficiency
• dehydrated hereditary stomatocytosis
• hemoglobin D disease
• gluthathione peroxidase deficiency
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction
• microcytic anemia with liver iron overload
• hypertriglyceridemia 2
• Heinz body anemia
• delta-beta-thalassemia
• hemoglobin E disease
• hemoglobin C-beta-thalassemia syndrome
• hemolytic anemia due to adenylate kinase deficiency
• dominant beta-thalassemia