SCGB1A1
Description
The SCGB1A1 (secretoglobin family 1A member 1) is a protein-coding gene located on chromosome 11.
Uteroglobin, or blastokinin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein encoded by the SCGB1A1 gene. It is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is specifically expressed in club cells in the lungs and has various names, including uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, club-cell secretory protein (CCSP), Clara-cell 16 kD protein (17 in rat/mice), club-cell-specific 10 kD protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club cell phospholipid-binding protein (hCCPBP), and secretoglobin 1A member 1 (SCGB1A1). Its precise physiological role is not yet fully understood, but it is thought to have several functions: immunomodulation, weak progesterone binding, inhibition of phospholipase A2 in vitro, binding to phosphatidylcholine and phosphatidylinositol, binding to fibronectin, and potentially preventing Goodpasture's syndrome-like glomerulopathy in mice. Uteroglobin knockout mice on different strains exhibit distinct phenotypes, including differences in response to respiratory challenges and changes in club cell morphology.
SCGB1A1 is also known as CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1.
