SCARNA14
Description
The SCARNA14 (small Cajal body-specific RNA 14) is a ncRNA gene located on chromosome 15.
SCARNA14 is a small nucleolar RNA (snoRNA) that is involved in the modification of ribosomal RNA (rRNA). It is a box C/D snoRNA, which means that it contains two conserved sequence motifs known as box C and box D. These motifs are important for the formation of snoRNPs and for the recognition of target sites on rRNA. SCARNA14 has been shown to direct the 2'-O-methylation of a specific adenosine residue in the 18S rRNA molecule.
SCARNA14 is a small nucleolar RNA (snoRNA) that is involved in the modification of ribosomal RNA (rRNA). snoRNAs are transcribed by RNA polymerase II and are found in the nucleolus, where they associate with proteins to form snoRNPs. snoRNPs guide the modification of rRNA by directing specific enzymatic activities to particular sites on the rRNA molecule. SCARNA14 is a box C/D snoRNA, which means that it contains two conserved sequence motifs known as box C and box D. These motifs are important for the formation of snoRNPs and for the recognition of target sites on rRNA. SCARNA14 has been shown to direct the 2'-O-methylation of a specific adenosine residue in the 18S rRNA molecule. This modification is thought to be important for the proper folding and function of the ribosome.
SCARNA14 is also known as U100.
