SCAND1
Description
The SCAND1 (SCAN domain containing 1) is a protein-coding gene located on chromosome 20.
The SCAN domain-containing protein 1 is a protein encoded by the SCAND1 gene in humans. The SCAN domain is a highly conserved motif found within a subfamily of zinc finger proteins. SCAND1 belongs to a family of genes with an isolated SCAN domain but no zinc finger motif. The SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, potentially involved in regulating transcriptional activity. Two transcript variants with different 5' UTRs, encoding the same protein, have been described. SCAND1 has been shown to interact with MZF1.
SCAND1 is also known as RAZ1, SDP1.
Associated Diseases
- cancer
- hemoglobin D disease
- dominant beta-thalassemia
- IRIDA syndrome
- overhydrated hereditary stomatocytosis
- hemoglobin C-beta-thalassemia syndrome
- sideroblastic anemia 3
- dehydrated hereditary stomatocytosis
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- cryohydrocytosis
