SBSN
The SBSN Gene: A Vital Player in Human Health
Description
The SBSN gene, officially known as subunit beta of the nuclear factor kappa B (NF-κB) complex, plays a crucial role in the regulation of gene expression. It forms an essential part of the NF-κB complex, a group of proteins that act as transcription factors, switching genes on or off to control various cellular processes.
The SBSN gene provides the instructions for producing the p50 subunit of the NF-κB complex. This subunit is responsible for binding to specific DNA sequences in the promoters of target genes, initiating the transcription process that leads to gene expression.
Associated Diseases
Dysfunction or mutations in the SBSN gene can lead to the development of several diseases:
- Ankylosing Spondylitis: A chronic inflammatory condition that affects the spine and other joints.
- Rheumatoid Arthritis: An autoimmune disorder that causes joint pain, swelling, and stiffness.
- Crohn's Disease: A type of inflammatory bowel disease that affects the digestive tract.
- Ulcerative Colitis: Another type of inflammatory bowel disease that affects only the colon.
- Multiple Myeloma: A cancer of plasma cells, a type of white blood cell.
Did you Know ?
Approximately 1 in 200 people carry a mutation in the SBSN gene, making it one of the most common genetic variants associated with autoimmune diseases.
