SALL4 : spalt like transcription factor 4
Description
The SALL4 (spalt like transcription factor 4) is a protein-coding gene located on chromosome 20.
The SALL4 gene is part of the SALL gene family, responsible for creating proteins involved in tissue and organ formation during embryonic development. SALL proteins are transcription factors that regulate gene activity by attaching to specific DNA regions. While the precise function of SALL4 protein remains unknown, based on similar proteins in other organisms like zebrafish and mice, it seems to be crucial for limb development. SALL4 might also be important for nerves that control eye movements and the formation of heart chamber dividers.
SALL4 is a crucial transcription factor for maintaining and renewing embryonic and hematopoietic stem cells.
SALL4 is also known as DRRS, HSAL4, IVIC, ZNF797.
Associated Diseases
- Duane-Radial ray syndrome
- IVIC syndrome
- Duane retraction syndrome
- Acro-renal-ocular syndrome
- Duane-radial ray syndrome
- Coloboma
