S100A7A
Description
The S100A7A (S100 calcium binding protein A7A) is a protein-coding gene located on chromosome 1.
S100A7A, also known as koebnerisin, is a protein belonging to the S100 family, a diverse group of calcium-binding proteins involved in various cellular processes. It was initially identified as being upregulated in psoriatic skin, suggesting a role in the characteristic skin lesions of psoriasis. S100A7A is expressed in various skin cells, including keratinocytes, melanocytes, and Langerhans cells, and is also found in the pilosebaceous unit and the dermis. It is produced by different cell types in the breast, including alveolar and myoepithelial cells. Beyond its potential role in psoriasis, S100A7A has antimicrobial properties, contributing to the host defense of the skin and digestive tract. Its antimicrobial activity has been demonstrated against bacteria such as E. coli, Pseudomonas aeruginosa, and Staphylococcus aureus. S100A7A's diverse functions highlight its importance in epidermal homeostasis, antimicrobial defense, and potentially in the development of various diseases.
S100A7A is also known as NICE-2, NICE2, S100A15, S100A7L1, S100A7f.
