S100A13
Description
The S100A13 (S100 calcium binding protein A13) is a protein-coding gene located on chromosome 1.
S100A13 is a protein encoded by the S100A13 gene in humans. It belongs to the S100 family of proteins, each containing two EF-hand calcium-binding motifs. S100 proteins are found in the cytoplasm and nucleus of various cells, regulating processes like cell cycle progression and differentiation. The S100 gene family has at least 13 members clustered on chromosome 1q21. S100A13 is widely expressed across different tissues, with particularly high levels in the thyroid gland. In smooth muscle cells, it co-localizes with other S100 family members in the nucleus and stress fibers, hinting at diverse roles in signal transduction. Multiple splice variants of the S100A13 gene exist, producing the same protein. S100A13 has been shown to interact with SYT1 and FGF1. Elevated S100A13 levels have been observed in cystic papillary thyroid carcinoma, and a link between S100A13 expression and chemotherapy resistance has been suggested in melanoma proteomics studies.
S100A13 plays a key role in the unconventional secretion of proteins lacking signal peptides. It binds two calcium ions per subunit and a single copper ion, with copper binding not affecting calcium binding. This protein is essential for the copper-dependent export of IL1A and FGF1 in response to stress. In the absence of calcium, S100A13 interacts with lipid vesicles containing phosphatidylserine, but not with those containing phosphatidylcholine.
S100A13 is also known as -.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- Alzheimer disease
- lung cancer
- Duane retraction syndrome
- cancer
