S100A11
Description
The S100A11 (S100 calcium binding protein A11) is a protein-coding gene located on chromosome 1.
S100A11 is a protein encoded by the S100A11 gene in humans. It belongs to the S100 family of proteins, characterized by two EF-hand calcium-binding motifs. It is a small, acidic protein found in a cluster with other S100 family members on chromosome 1q21. It was initially discovered in chicken gizzard muscles and is involved in cell motility, invasion, and tubulin polymerization. Its altered expression and chromosomal rearrangements have been linked to tumor metastasis. It is highly expressed in various tissues, including lungs, pancreas, heart, placenta, and kidneys, and at lower levels in skeletal muscle, liver, and brain. S100A11 is implicated in membrane and cytoskeletal dynamics, vesicular transport, and processes of endo- and exocytosis. It interacts with various cytoskeletal structures like tubulin, actin, and intermediate filaments, as well as annexin I and annexin II. S100A11 can regulate actin reorganization and plays a role in the formation of protrusions by metastatic cells.
S100A11 promotes the differentiation and hardening of keratinocytes, the cells that make up the outer layer of skin.
S100A11 is also known as HEL-S-43, MLN70, S100C.
