S100A10
Description
The S100A10 (S100 calcium binding protein A10) is a protein-coding gene located on chromosome 1.
S100A10, also known as p11, is a protein encoded by the S100A10 gene. It belongs to the S100 family of proteins, characterized by two EF-hand calcium-binding motifs. These proteins are found in the cytoplasm and nucleus of various cells, where they regulate processes like cell cycle progression and differentiation. S100A10 is implicated in exocytosis and endocytosis through F-actin reorganization. In the brain, p11 is linked to neurotransmitter transport and has been associated with mood regulation. Its interaction with serotonin-signaling proteins and its correlation with mood disorders make it a potential target for drug therapy. The S100 gene family, containing at least 13 members, is located on chromosome 1q21. Humans have 19 known S100 family members.
S100A10 promotes the dimerization of ANXA2/p36, which may regulate protein phosphorylation. The monomeric form of ANXA2 is preferentially targeted by tyrosine-specific kinases in vitro.
S100A10 is also known as 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10.
