RUNX1T1 : RUNX1 partner transcriptional co-repressor 1
Description
The RUNX1T1 (RUNX1 partner transcriptional co-repressor 1) is a protein-coding gene located on chromosome 8.
The RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
The RUNX1T1 gene product, also known as ETO, is a transcriptional corepressor that silences gene activity. It achieves this by binding to proteins that normally activate genes, effectively blocking their function. ETO also collaborates with other corepressors to maintain gene silencing. ETO's activity is further demonstrated by its ability to suppress MMP7 expression in a ZBTB33-dependent manner and to inhibit transactivation mediated by TCF12. Moreover, ETO acts as a negative regulator of adipogenesis. In leukemic cells, a fusion protein formed by ETO and AML1 (AML1-MTG8/ETO) contributes to leukemogenesis and supports the self-renewal of hematopoietic stem and progenitor cells.
RUNX1T1 is also known as AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2.
