RUNX1-IT1
Description
The RUNX1-IT1 (RUNX1 intronic transcript 1) is a ncRNA gene located on chromosome 21.
RUNX1-IT1 is a long non-coding RNA (lncRNA) located on chromosome 21. It is transcribed from the opposite strand of the RUNX1 gene, which encodes a crucial transcription factor involved in hematopoiesis (blood cell development). Studies indicate that RUNX1-IT1 might regulate RUNX1 expression, influencing blood cell formation. Furthermore, RUNX1-IT1 appears to be implicated in various cancers, especially leukemias, and its dysregulation may contribute to abnormal RUNX1 activity. While the precise molecular mechanisms remain to be fully understood, RUNX1-IT1 is thought to act through intricate interactions with other molecules, possibly serving as a scaffold or regulator of gene expression.
RUNX1-IT1 is a long non-coding RNA (lncRNA) that is located on chromosome 21 and is transcribed from the opposite strand of the RUNX1 gene. It has been shown to play a role in hematopoiesis, with studies suggesting that it may regulate the expression of RUNX1, a key transcription factor involved in blood cell development. RUNX1-IT1 also seems to be involved in various cancers, particularly leukemias, and its deregulation is linked to aberrant RUNX1 expression. Its exact mechanism of action remains to be fully elucidated, but it is believed to function via complex interactions with other molecules, potentially acting as a scaffold or regulator of gene expression.
RUNX1-IT1 is also known as C21orf96.
