RUFY3

Description

The RUFY3 (RUN and FYVE domain containing 3) is a protein-coding gene located on chromosome 4.

RUFY3 is a protein also known as RUN and FYVE domain-containing protein 3, Rap2-interacting protein x, and Single axon-regulated protein. It plays a role in neuronal polarity formation and axon growth. It is involved in the formation of a single axon by developing neurons and may inhibit the formation of additional axons by inhibiting PI3K in minor neuronal processes. RUFY3 also plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery and in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Additionally, RUFY3 promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. It interacts with several proteins, including PAK1, Ras-related Rab-5 proteins, Ras-related Rap-2 proteins, PIK3CA, PIK3R1, FSCN1, and DBN1.

RUFY3 is also known as RIPX, SINGAR1, ZFYVE30.

Associated Diseases

WES Whole Exome Sequencing