RSF1
Description
The RSF1 (remodeling and spacing factor 1) is a protein-coding gene located on chromosome 11.
Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.
RSF1 is a regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. It binds to core histones together with SMARCA5 and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. RSF1 directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively. The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. RSF1 facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, RSF1 represses TNF-alpha induced NF-kappa-B transcription activation. RSF1 represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.
RSF1 is also known as HBXAP, RSF-1, XAP8, p325.
