RPS6KA5
Description
The RPS6KA5 (ribosomal protein S6 kinase A5) is a protein-coding gene located on chromosome 14.
Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.
== Interactions == RPS6KA5 has been shown to interact with CREB1.
RPS6KA5 is a serine/threonine-protein kinase that plays a crucial role in regulating gene expression and cellular responses to various stimuli. It phosphorylates several transcription factors, including CREB1, ATF1, RELA, STAT3, and ETV1/ER81, thereby modulating their activity. RPS6KA5 also contributes to gene activation by phosphorylating histone H3, which can lead to the transcription of immediate early genes like c-fos/FOS and c-jun/JUN. Furthermore, RPS6KA5 participates in the regulation of inflammatory genes by interacting with glucocorticoid receptors and modulating the activity of NF-κB. RPS6KA5 also plays a role in neuronal cell death and growth factor signaling through its interactions with other proteins. It interacts with MAPK1/ERK2, MAPK3/ERK1, and MAPK14/p38-alpha, and its activity is influenced by the MEK/ERK pathway. RPS6KA5 also associates with CREBBP and EP300.
RPS6KA5 is also known as MSK1, MSPK1, RLPK.
