RPL36A-HNRNPH2
Description
The RPL36A-HNRNPH2 (RPL36A-HNRNPH2 readthrough) is a protein-coding gene located on chromosome X.
The RPL36A-HNRNPH2 fusion gene is a chimeric transcript formed by a chromosomal translocation event involving the ribosomal protein L36A (RPL36A) and the heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) genes. This fusion has been observed in various cancers, including acute myeloid leukemia (AML), and is associated with aggressive disease progression and poor prognosis. The fusion protein is likely to have a combined functionality derived from both parental proteins, potentially affecting ribosomal function and RNA processing. Further research is needed to fully understand the oncogenic mechanisms of this fusion gene.
The RPL36A-HNRNPH2 fusion gene is a rare chimeric transcript that combines the ribosomal protein L36A (RPL36A) and the heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) genes. This fusion is associated with various cancers, including acute myeloid leukemia (AML), and has been shown to have potential oncogenic properties. The fusion gene, resulting from a chromosomal translocation, generates a novel protein that may contribute to tumorigenesis by disrupting normal cellular processes. While the exact mechanisms underlying its oncogenic potential are still being investigated, its presence is correlated with aggressive disease progression and poor prognosis in certain cancers.
RPL36A-HNRNPH2 is also known as -.
