RPL10A
Description
The RPL10A (ribosomal protein L10a) is a protein-coding gene located on chromosome 6.
The RPL10A gene encodes a ribosomal protein that is a component of the 60S subunit, which is part of the ribosome. Ribosomes are essential for protein synthesis, and the 60S subunit is responsible for catalyzing the formation of peptide bonds. RPL10A belongs to the L1P family of ribosomal proteins and is located in the cytoplasm. The expression of this gene can be regulated by various factors, including the immunosuppressive drug cyclosporin-A (CsA) and developmental stage. It is downregulated in the thymus by CsA and in neural precursor cells during development. This gene was previously known as NEDD6 but has been renamed RPL10A. Like other genes encoding ribosomal proteins, RPL10A has multiple processed pseudogenes dispersed throughout the genome.
RPL10A is a component of the large ribosomal subunit, which is essential for protein synthesis in the cell. Its role in this process has been documented in multiple studies (PubMed:12962325, PubMed:23636399, PubMed:32669547).
RPL10A is also known as CSA19, Csa-19, L10A, NEDD6, uL1.
Associated Diseases
- Duchenne muscular dystrophy
- cystic fibrosis
- Becker muscular dystrophy
- qualitative or quantitative defects of dystrophin
- thyroid gland adenocarcinoma
- aniridia
- hemophilia B
- cystinosis
- hemophilia A
- Alport syndrome
- ulnar hemimelia
