ROS1

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Description

The ROS1 gene, encodes a receptor tyrosine kinase (RTK) that plays a crucial role in cell growth, survival, and differentiation. In normal cells, ROS1 signaling is tightly regulated, but mutations or rearrangements in this gene can lead to uncontrolled activation, driving tumor development. ROS1 fusions, where the ROS1 gene is fused to another gene, are commonly found in various cancers, including non-small cell lung cancer (NSCLC), glioblastoma, and colorectal cancer. These fusions create chimeric proteins with constitutive activation of the ROS1 kinase domain, leading to aberrant signaling pathways that promote tumor growth and metastasis.

Associated Diseases

• Non-small cell lung cancer (NSCLC)
• Glioblastoma
• Colorectal cancer
• Breast cancer
• Thyroid cancer
• Osteosarcoma

Did you know?

ROS1 fusions were first discovered in a patient with a rare type of lung cancer called pulmonary adenocarcinoma.