RNF183

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Description

The RNF183 (ring finger protein 183) is a protein-coding gene located on chromosome 9.

Ring finger protein 183 is a protein in humans that is encoded by the RNF183 gene.

RNF183 acts as an E3 ubiquitin ligase, attaching ubiquitin moieties to target proteins. It triggers apoptosis under prolonged ER stress by ubiquitinating and degrading BCL2L1. Additionally, RNF183 may collaborate with FATE1 to control BIK protein levels, influencing apoptotic signaling.

RNF183 is also known as -.

Associated Diseases

• urinary bladder carcinoma
• cancer
• colorectal cancer