RNF169
Description
The RNF169 (ring finger protein 169) is a protein-coding gene located on chromosome 11.
RNF169 is a protein that plays a role in DNA damage repair. It functions by regulating the recruitment of other proteins to damaged DNA, influencing the choice of repair pathways. RNF169 specifically promotes homologous recombination repair (HRR) and single-strand annealing (SSA) while inhibiting non-homologous end joining (NHEJ). Importantly, RNF169's E3 ubiquitin ligase activity is not required for its role in DNA repair.
RNF169 is also known as -.
