RNF167
Description
The RNF167 (ring finger protein 167) is a protein-coding gene located on chromosome 17.
RNF167 is an E3 ubiquitin-protein ligase that regulates the TORC1 signaling pathway. It positively regulates TORC1 independently of arginine levels by ubiquitinating and degrading CASTOR1, which releases the GATOR2 complex. RNF167 also negatively regulates TORC1 in response to leucine deprivation by ubiquitinating SESN2, promoting its interaction with the GATOR2 complex. In addition to its role in TORC1 signaling, RNF167 is involved in protein trafficking and localization, acting as a regulator of synaptic transmission by ubiquitinating and degrading the AMPAR receptor GluA2/GRIA2. It does not ubiquitinate GluA1/GRIA1. RNF167 also regulates the recycling endosome pathway by ubiquitinating VAMP3 and regulates lysosome positioning by ubiquitinating and degrading ARL8B. RNF167 plays a role in growth regulation, potentially by mediating ubiquitination of SLC22A18, and acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N.
RNF167 is also known as 5730408C10Rik, LP2254, RING105.
