RNF157
Description
The RNF157 (ring finger protein 157) is a protein-coding gene located on chromosome 17.
RNF157 is an E3 ubiquitin ligase that plays a crucial role in neuronal survival by ubiquitinating APBB1, leading to its degradation by the proteasome and preventing apoptosis. It also contributes to dendrite growth and maintenance, suggesting a dual role in neuronal function. RNF157's ligase activity is not essential for dendrite development. It may act as a scaffold molecule, potentially regulating this process. RNF157 functions as a downstream effector in the PI3K and MAPK signaling pathways, influencing cell cycle regulation.
RNF157 is also known as -.
Associated Diseases
- early-onset non-syndromic cataract
- hereditary hyperferritinemia with congenital cataracts
- isolated ectopia lentis
- cataract
- cataract 38
- cataract 13 with adult I phenotype
- granular corneal dystrophy type I
