RNF152
Description
The RNF152 (ring finger protein 152) is a protein-coding gene located on chromosome 18.
RNF152 acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. It catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Additionally, RNF152 mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. RNF152 also mediates 'Lys-48'-linked polyubiquitination of target proteins, leading to their degradation through the proteasome. Overexpression of RNF152 induces apoptosis.
RNF152 is also known as -.
