RNF123
Description
The RNF123 (ring finger protein 123) is a protein-coding gene located on chromosome 3.
RNF123 is a human gene encoding an enzyme called E3 ubiquitin-protein ligase RNF123. This protein contains a RING finger motif, known to be involved in protein-protein and protein-DNA interactions. Increased expression of the RNF123 gene has been linked to laminopathies, and it plays a role in the degradation of chromatin-associated proteins such as HP1.
RNF123 is a catalytic subunit of the KPC complex, acting as an E3 ubiquitin-protein ligase. It promotes the ubiquitination and proteasome-mediated degradation of CDKN1B, a cyclin-dependent kinase inhibitor, at the G0-G1 transition of the cell cycle. Additionally, it regulates NF-kappa-B signaling by promoting the maturation of the NFKB1 component of NF-kappa-B through ubiquitination of the NFKB1 p105 precursor, leading to the generation of the active NFKB1 p50 subunit. RNF123 also functions as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1, independently of its E3 ligase activity. It interacts with the N-terminal CARD domains of RIGI and IFIH1, competing with the downstream adapter MAVS.
RNF123 is also known as FP1477, KPC1.
